The only method of control currently used is the application of pesticides. There are a number of natural enemies (predators, parasitoids, and pathogens) that attack this insect, but these usually do not significantly affect its numbers.

Rainy weather helps to reduce populations of soybean aphid. Raindrops may knock aphids off plants and high humidity increases the chance for fungal diseases to infect the insects.

Research is underway to develop soybean cultivars that are resistant to the soybean aphid.